CSNK1A1L,酪蛋白激酶1/casein kinase Iα抗体

产品编号HZ-12943R
英文名称CSNK1A1L
中文名称酪蛋白激酶1/casein kinase Iα抗体
别 名Casein kinase 1, alpha 1 like; casein kinase 1, alpha 1-like; Casein kinase I alpha S like; Casein kinase I isoform alpha like; CK1; CKI alpha like; MGC33182; OTTHUMP00000018267; RP11 532O21.2; KC1AL_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导 激酶和磷酸酶 细胞分化
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Cow, Rabbit, Sheep,
CSNK1A1L,酪蛋白激酶1/casein kinase Iα抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CSNK1A1L
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CSNK1A1L,酪蛋白激酶1/casein kinase Iα抗体PubMedPubMed
产品介绍background:
Casein kinase I (also designated CKI) and casein kinase II (CKII) compose a family of serine/threonine protein kinases which are present in all eukaryotes examined to date. Casein kinase I family members, which include casein kinase I Alpha, I Gamma, I Delta and I Epsilon, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair, membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation. Casein kinase I isoform alpha-like (CSNK1A1L) is a 337 amino acid protein that shares a high degree of sequence similarity with the alpha isoform of casein kinase 1. CSNK1A1L resides in the cytoplasm and participates in the Wnt signaling pathway. By utilizing ATP within its protein kinase domain, CSNK1A1L phosphorylates a large number of proteins.

Function:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. CSNK1A1L can phosphorylate a large number of proteins and participates in Wnt signaling.

Subcellular Location:
Cytoplasmic.

Similarity:
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Contains 1 protein kinase domain

Database links:
UniProtKB/Swiss-Prot: Q8N752.2

CSNK1A1L,酪蛋白激酶1/casein kinase Iα抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.