FITC标记的分选连接蛋白2抗体
产品名称： FITC标记的分选连接蛋白2抗体
英文名称： Anti-SNX2/FITC
产品编号： HZ-12249R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SNX2/FITC Conjugated antibody
FITC标记的分选连接蛋白2抗体
| 英文名称 | Anti-SNX2/FITC |
| 中文名称 | FITC标记的分选连接蛋白2抗体 |
| 别 名 | MGC5204; SNX 2; SNX2; SNX2_HUMAN; Sorting nexin 2; Sorting nexin-2; Transformation related gene 9 protein; Transformation-related gene 9 protein; TRG 9; TRG-9; TRG9. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 生长因子和激素 转录调节因子 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 58kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Human SNX2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Sorting nexin 1 (SNX1) is a member of a large family of hydrophilic proteins that interact with a variety of receptor types and are involved in intracellular trafficking. SNX1 and the related splice variant, SNX1A, bind the epidermal growth factor (EGF) receptor and facilitate its transport to lysosome, thereby contributing to the degradation of the receptor. SNX2 and SNX4 share a high degree of amino acid similarity with SNX1, as they all contain a characteristic phox homology (PX) domain. These proteins are all partially associated with cellular membranes and they likewise associate with EGF, PDGF and insulin receptor tyrosine kinases. These nexins are widely expressed and yet have various tissue distribution patterns. Additionally, the sorting nexins can associate with each other and with a variety of other cellular proteins, suggesting that they exist as part of multi-subunit complexes. The related protein, SNX3, comprises a distinct subgroup of nexins that share less sequence similarity outside of the PX domain and have dramatically different binding affinities for the tyrosine kinase receptors. Function: May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Subunit: Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts with FNBP1. Interacts with SNX6. Subcellular Location: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Similarity: Belongs to the sorting nexin family. Contains 1 PX (phox homology) domain. Database links: UniProtKB/Swiss-Prot: O60749.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
排序连接蛋白1（SNX1）是一大类亲水性蛋白质家族的成员，与多种受体类型相互作用，参与细胞内运输。SNX1和相关的剪接变异体SNX1A结合表皮生长因子（EGF）受体并促进其转运到溶酶体，从而促进受体的降解。SNX2和SNX4与SNX1具有高度的氨基酸相似性，因为它们都包含一个特征性的phox同源性（PX）结构域。这些蛋白都部分与细胞膜相关，并且它们同样与EGF、PDGF和胰岛素受体酪氨酸激酶相关。这些NEXIN广泛表达，但具有多种组织分布模式。此外，分选连接蛋白可以相互结合并与多种其他细胞蛋白结合，表明它们作为多亚基复合物的一部分存在。相关蛋白SNX3包括连接蛋白的不同亚群，其在PX结构域外具有较少的序列相似性，并且对酪氨酸激酶受体具有显著不同的结合亲和力。