Anti-MMP6/MPHOSPH6抗体
产品名称： Anti-MMP6/MPHOSPH6抗体
英文名称： MMP6/MPHOSPH6
产品编号： YB--17687R
产品价格： null
产品产地： 中国/美国
品牌商标： Ybscience
更新时间： 2023-08-17T10:29:50
使用范围： 科研使用
上海钰博生物科技有限公司
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- 邮编 : 200612
- 所在区域 : 上海
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Anti-MMP6/MPHOSPH6抗体
| 产品编号 | YB-17687R |
| 英文名称 | MMP6/MPHOSPH6 |
| 中文名称 | 基质金属蛋白酶6抗体 |
| 别 名 | M phase phosphoprotein 6; M phase phosphoprotein 6 variant; M-phase phosphoprotein 6; MT-MMP-6; MMP 6; MMP; MPH6_HUMAN; MPHOSH6; MPHOSPH 6; Mphosph6; MPP 6; MPP; MPP6. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 细胞粘附分子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Rabbit, Sheep, |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 19kDa |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MMP6:1-80/160 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: The matrix metalloproteinases (MMPs) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. MMP catalysis requires both calcium and zinc. Membrane-type matrix metalloproteinases are type I membrane proteins that function to activate other MMPs. MT-MMP activation appears to be mediated by members of the proprotein convertase family, suggesting that a proprotein convertase/MT-MMP/MMP cascade may be involved in the regulation of ECM turnover. MT-MMP-6 (also known as MMP-25, MT6-MMP or Leukolysin) is the second GPI-anchored proteinase in the MMP family. Similar to MMP-3, MT-MMP-6 is able to cleave type IV collagen, Fibronectin, fibrin and gelatin. However, MT-MMP-6 cannot cleave Laminin-1 or activate progelatinase B. MT-MMP 6 is expressed in leukocytes, lung and spleen Function: RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. Subunit: Associates with the RNA exosome complex, probably mediated by EXOSC10. Interacts with ARHGAP18, EXOSC10 and SKIV2L2. Subcellular Location: Nucleus > nucleolus. Cytoplasm. Cytoplasmic in M phase. Post-translational modifications: Phosphorylated in M (mitotic) phase. Similarity: Belongs to the MPP6 family. SWISS: Q99547 Gene ID: 10200 Database links: Entrez Gene: 10200 Human Entrez Gene: 68533 Mouse Omim: 605500 Human SwissProt: Q99547 Human SwissProt: Q9D1Q1 Mouse Unigene: 344400 Human Unigene: 181836 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |
 Paraformaldehyde-fixed, paraffin embedded (Rat urinary bladder); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MMP6/MPHOSPH6) Polyclonal Antibody, Unconjugated (bs-17687R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
 Paraformaldehyde-fixed, paraffin embedded (Rat stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MMP6/MPHOSPH6) Polyclonal Antibody, Unconjugated (bs-17687R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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