FITC标记的蛋白激酶Aγ抗体
产品名称： FITC标记的蛋白激酶Aγ抗体
英文名称： Anti-PKA gamma/FITC
产品编号： HZ-3964R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-PKA gamma/FITC Conjugated antibody
FITC标记的蛋白激酶Aγ抗体
| 英文名称 | Anti-PKA gamma/FITC |
| 中文名称 | FITC标记的蛋白激酶Aγ抗体 |
| 别 名 | KAPG; PKA C gamma; PRKACG; Protein kinase cAMP dependent catalytic gamma; Serine (threonine) protein kinase; KAPCG_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PKA gamma |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PKA (or cAPK) is a cyclic AMP dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, plus gene transcription. PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunit (RI and RII) and three C subunit isoforms (C alpha, C beta, and C gamma) have been identified each possessing distinct cAMP binding properties and resulting in different phosphorylation states. C subunit is activated through autophosphorylation and direct phosphorylation at Thr197 by PDK-1. Tissue specific expression of C gamma, indicates pressure on C gamma during evolution, acting to modulate it in a functionally specific way. Certain amino acid substitutions make C gamma a distinct member of the cAMP dependent subfamily of protein kinases, and suggest that C gamma may be distinct in its protein substrate specificity or its interaction with the different regulatory subunits. Function: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Subunit: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Tissue Specificity: Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript. Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Database links: UniProtKB/Swiss-Prot: P22612.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PKA（或CAPK）是一种环AMP依赖性蛋白激酶。在第二信使cAMP激活时，PKA介导多种细胞机制，包括增殖、离子转运、代谢调控、基因转录等。PKA由两个亚基的两个二聚体组成，R（调节）和C（催化）。已经鉴定出两个家族的R亚基（RI和RII）和三个C亚基异构体（Cα，Cβ和Cγ），它们各自具有不同的cAMP结合性质，并导致不同的磷酸化状态。C亚单位通过磷酸化和直接磷酸化在TH197中被PDK-1激活。Cγ的组织特异性表达，表明Cγ在进化过程中的压力，以功能特异的方式调节它。某些氨基酸取代使Cγ成为蛋白激酶cAMP依赖亚家族的不同成员，并提示Cγ在其蛋白底物特异性或其与不同调节亚基的相互作用中可能是不同的。