ENPP6,磷酸酶/磷酸二酯酶家族成员6抗体

产品编号HZ-13076R
英文名称ENPP6
中文名称磷酸酶/磷酸二酯酶家族成员6抗体
别 名B830047L21Rik; E-NPP 6; Ectonucleotide pyrophosphatase/phosphodiesterase 6; ectonucleotide pyrophosphatase/phosphodiesterase family member 6; ENPP 6; NPP 6; NPP6; ENPP6_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 神经生物学 激酶和磷酸酶 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse,
ENPP6,磷酸酶/磷酸二酯酶家族成员6抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量46kDa
细胞定位细胞膜 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ENPP6
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ENPP6,磷酸酶/磷酸二酯酶家族成员6抗体PubMedPubMed
产品介绍background:
NPP6 is a 440 amino acid member of the nucleotide pyrophosphatase/phosphodiesterase family. NPP6 is a secreted and single-pass type I membrane protein. Predominantly expressed in brain and kidney, NPP6 is a choline-specific glycerophosphodiester phosphodiesterase. NPP6 can hydrolyze the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine, glycerophosphorylcholine, sphingosylphosphorylcholine and lysophosphatidylcholine (LPC). NPP6 has been found to have a preference for LPC with polyunsaturated or short fatty acids. The gene encoding NPP6 maps to human chromosome 4, which consists of approximately 6% of the human genome and nearly 900 genes. Chromosome 4 is associated with Huntington's disease, FGFR-3, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.

Function:
ENPP6 is a choline-specific glycerophosphodiester phosphodiesterase, which hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5 prime-monophosphate. It hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. ENPP6 has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. ENPP6 also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. ENPP6 is predominantly expressed in kidney and brain.

Subunit:
Homodimer; disulfide-linked.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Secreted. Note: A minor secreted form also exists.

ENPP6,磷酸酶/磷酸二酯酶家族成员6抗体Tissue Specificity:
Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level).

DISEASE:

Similarity:
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Gene ID:
133121

Database links:
Entrez Gene: 133121 Human
Entrez Gene: 320981 Mouse
Entrez Gene: 306460 Rat
SwissProt: Q6UWR7 Human
SwissProt: Q8BGN3 Mouse
SwissProt: B0BND0 Rat
Unigene: 297814 Human
Unigene: 211429 Mouse
Unigene: 8484 Rat

ENPP6,磷酸酶/磷酸二酯酶家族成员6抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.