Name

名称

Pathway/Target

通路/靶点

Package

包装规格

Price(RMB)

价格(人民币)

Cat#

货号

Functions

功能

A769662

AMPK/mTOR

10 mg

1190

C2769-10

C2769-10s

A769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator. Useful for both cell survival and cell proliferation studies.

A769662是一种高效的可逆的AMPK激活剂。可用于细胞存活和细胞增殖方面的研究。

A83-01

TGF-β

2 mg

890

C2831-2

C2831-2s

A83-01 inhibits the TGF-β-induced epithelial-to-mesenchymal transition via the inhibition of Smad2 phosphorylation. A83-01 has been used to generate rat and human iPS cells towards a mouse ES cell like self-renewal state.

A83-01通过抑制Smad2磷酸化来抑制TGF-β诱导的上皮-间质转分化。用于使大鼠和人类的iPS细胞倾向于类似小鼠的ES细胞的自我更新状态。

BEZ235

PI3K/mTOR

2 mg

490

C2392-2

C2392-2s

BEZ235 is a dual inhibitor of the PI3K and the downstream mTOR. It inhibits the activation of the downstream effectors Akt, S6 ribosomal protein, and 4EBP1 in breast.

BEZ235是一个针对PI3K和下游mTOR的双重抑制剂。它可以抑制下游效应分子Akt，S6核糖体蛋白以及4EBP1。

BIX-01294

Epigenetic-G9a HMT

5 mg

890

C2491-5

C2491-5s

BIX-01294 is a selective inhibitor of G9a histone methyl transferase.   It enhances reprogramming efficiency of neural progenitor cells to the same levels as when Oct4, Klf4, Sox2 and c-Myc were introduced to somatic cells for generation of iPS cells.

BIX-01294是G9a组蛋白甲基转移酶的抑制剂。能够增强神经前体细胞的重编程效率，使其能够达到体细胞转入Oct4, Klf4, Sox2 和c-Myc产生iPS细胞同等效率。

CHIR99021

Wnt/GSK-3β

2 mg

2090

C2447-2

C2447-2s

CHIR99021 is the most selective inhibitor of glycogen synthase kinase 3β reported so far.  It worked in long term expansion of murine embryonic stem cells in conjunction with MEK/MAPK inhibitor PD0325901 and FGFR inhibitor SU5402.

CHIR99021是目前为止报道的GSK-3β的选择性最好的抑制剂。与MEK/MAPK 抑制剂PD0325901和FGFR抑制剂SU5402一起用于小鼠胚胎干细胞的长期扩增中。

CP-690550

JAK

2 mg

790

C2716-2

C2716-2s

CP-690550 is a potent and selective JAK inhibitor.  In cellular assays it potently inhibits signaling through JAK1 and JAK3 with 5-100 fold selectivity over JAK2.

CP-690550是一个JAK的高效的选择性抑制剂。在细胞实验中它可以通过比抑制JAK2高出5-100倍的效率抑制JAK1和JAK3，以此高效抑制信号传导。

Cyclopamine

Hedgehog/Smo

2 mg

1290

C2925-2

C2925-2s

Cyclopamine is a specific Inhibitor of hedgehog (Hh) signaling via direct inhibition of Smoothened. Cyclopamine could be used to induce stem cell differentiation towards definitive endoderm pancreatic islet cells, and to inhibit stem-like cancer cell proliferation and block tumor engraftment.

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