分子量:13.4 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human ROR1 (39-151, Ig-like domain), His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human ROR1 (39-151, Ig-like domain), His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 13.4 kDa. The predicted N-terminus is Glu 39. The reducing (R) protein migrates as 30 kDa in SDS-PAGE  due to glycosylation.

产品背景:Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.