DCDC2,双皮层蛋白结构域蛋白DCDC2抗体

产品编号HZ-11824R
英文名称DCDC2
中文名称双皮层蛋白结构域蛋白DCDC2抗体
别 名DCDC 2; DCDC2; DCDC2_HUMAN; DCDC2A; Doublecortin domain containing 2; Doublecortin domain-containing protein 2; HGNC:18141; KIAA1154; Protein RU2S; RU2; RU2S; RU2S protein.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Cow, Horse, Sheep,
DCDC2,双皮层蛋白结构域蛋白DCDC2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DCDC2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DCDC2,双皮层蛋白结构域蛋白DCDC2抗体PubMedPubMed
产品介绍background:
The DCDC2 gene encodes the DCDC2 protein (Doublecortin-containing protein 2, RU2, RU2S) which contains two Doublecortin peptide domains similar to those in the Doublecortin gene. DCDC2 is transcribed as a “normal” gene, which results in a sense transcript (RU2S), but when it is transcribed in the opposite direction, a shorter antisense transcript (RU2AS), which is found in tumors, results. The DCDC2 protein demonstrates ubiquitous expression, whereas RU2AS expression is restricted to normal kidney, bladder, liver and testis, and to tumors of various histologic origins. The deduced DCDC2 protein contains 476 amino acids, while the RU2AS protein contains 84 residues. There is a significant association between dyslexia and several SNPs within the DCDC2 gene.

Function:
May be involved in neuronal migration during development of the cerebral neocortex.

Tissue Specificity:
Ubiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus.

DCDC2,双皮层蛋白结构域蛋白DCDC2抗体DISEASE:
Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:600202]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.

Similarity:
Contains 2 doublecortin domains.

Database links:
UniProtKB/Swiss-Prot: Q9UHG0.2

DCDC2,双皮层蛋白结构域蛋白DCDC2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.