AGR2抗体
Applications
| In-house applications |
ELISA, WB, IHC, IP, FC, IF Application not tested? Please see our Guarantee. |
| Published applications |
IHC, WB |
Publications |
5 citations –view here |
| Species specificity |
Human,Mouse,Rat; other species not tested. |
| Published Species |
Human |
|
Images
Prev12Next
 mouse stomach tissue were subjected to SDS PAGE followed by western blot with 12275-1-AP(AGR2 antibody) at dilution of 1:1000 Immunohistochemical of paraffin-embedded human breast cancer using 12275-1-AP(AGR2 antibody) at dilution of 1:100 (under 10x lens) IP Result of anti-AGR2 (IP:12275-1-AP, 4ug; Detection:12275-1-AP 1:1000) with SW 1990 cells lysate 2400ug. Immunofluorescent analysis of MCF-7 cells using 12275-1-AP( AGR2 Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) 1X10^6 MCF-7 cells were stained with 0.2ug AGR2 antibody (12275-1-AP, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.
|
| Positive WB detected in |
Mouse stomach tissue, human colon tissue, human stomach tissue, mouse small intestine tissue, rat colon tissue, rat stomach tissue, SW 1990 cells |
| Positive IP detected in |
SW 1990 cells |
| Positive IHC detected in |
Human breast cancer tissue, human colon tissue |
| Positive IF detected in |
MCF-7 cells |
| Positive FC detected in |
MCF-7 cells |
| Recommended dilution |
WB : 1:1000-1:10000
IP : 1:500-1:5000
IHC : 1:20-1:200
IF : 1:10-1:100 |
AGR2抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen |
AGR2 fusion protein ag2919 |
Full name |
Anterior gradient homolog 2 (Xenopus laevis) |
Calculated molecular
weight |
175aa,20 kDa |
Observed molecular
weight |
17-20kd |
GenBank accession
number |
BC015503 |
Gene ID (NCBI) |
10551 |
| Gene symbol |
AGR2 |
Synonyms |
AG 2, AG2, AGR2, GOB 4, HAG 2, HPC8, PDIA17, XAG 2 |
Background AGR2抗体
|
AGR2, also named AG2 or HPC8, encodes anterior gradient protein 2 homolog which belongs to the AGR family. It is a secreted protein localized in endoplasmic reticulum. AGR2 plays roles in MUC2 post-transcriptional synthesis,secretion and production of mucus by intestinal cells. AGR2 was significantly elevated in the pancreatic juice from patients with pre-malignant conditions as well as pancreatic cancer compared to control pancreatic juice samples. AGR2 levels in pancreatic juice could potentially be used to aide in assessment of high-risk patients undergoing endoscopic procedures. AGR2抗体
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