FITC标记的异质核核糖核蛋白AUF1抗体
产品名称： FITC标记的异质核核糖核蛋白AUF1抗体
英文名称： Anti-hnRNP D/AUF1/FITC
产品编号： HZ-17331R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-hnRNP D/AUF1/FITC Conjugated antibody
FITC标记的异质核核糖核蛋白AUF1抗体
| 英文名称 | Anti-hnRNP D/AUF1/FITC |
| 中文名称 | FITC标记的异质核核糖核蛋白AUF1抗体 |
| 别 名 | ARE binding protein AUFI type A; AU-rich element RNA-binding protein 1; AUF; AUF1; AUF1A; Heterogeneous nuclear ribonucleoprotein D0; hnRNP D; hnRNP D0; hnRNPD; hnRNPD0; HNRPD; HNRPD_HUMAN; P37. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 结合蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, Dog, Pig, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human hnRNP D/AUF1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008] Function: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Subcellular Location: Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Post-translational modifications: Arg-345 is dimethylated, probably to asymmetric dimethylarginine. Methylated by PRMT1, in an insulin-dependent manner. The PRMT1-mediated methylation regulates tyrosine phosphorylation. Similarity: Contains 2 RRM (RNA recognition motif) domains. Database links: Entrez Gene: 3184 Human Entrez Gene: 11991 Mouse Entrez Gene: 79256 Rat GenBank: NP_112738.1 Human Omim: 601324 Human SwissProt: Q14103 Human SwissProt: Q60668 Mouse SwissProt: Q9JJ54 Rat Unigene: 480073 Human Unigene: 150231 Mouse Unigene: 94022 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因属于普遍表达的异质核核糖核蛋白（HNRNPs）亚家族。HNRNPs是核酸结合蛋白，它们与异质性核RNA（HNRNA）复合。这些蛋白与核内的前mRNA相关联，并似乎影响前mRNA处理和mRNA代谢和转运的其他方面。虽然所有的HNRNPs都存在于细胞核中，有些似乎在细胞核和细胞质之间穿梭。HNRNP蛋白具有不同的核酸结合特性。由该基因编码的蛋白质具有与RNAs结合的准RRM结构域的两个重复。它定位于细胞核和细胞质。这种蛋白与mRNA稳定性的调节有牵连。该基因的选择性剪接导致四个转录变体。[ RefSeq，JUL 2008 ]