PGGT1B,香叶烯基转移酶1β抗体

产品编号HZ-9372R
英文名称PGGT1B
中文名称香叶烯基转移酶1β抗体
别 名PGGT1B; GGTase-I beta; GGTase-1 beta; BGGI; Geranylgeranyl transferase type I subunit beta; Geranylgeranyl transferase type-1 subunit beta; GGTase-I-beta; GGTI; PGGT1B; PGTB1_HUMAN; Type I protein geranyl-geranyltransferase subunit beta; PGGT1β; GGTase-1 β; GGTase-I β.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Horse,
PGGT1B,香叶烯基转移酶1β抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PGGT1 beta
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PGGT1B,香叶烯基转移酶1β抗体PubMedPubMed
产品介绍background:
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]

Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Acts on the Rac1, Rac2, Rap1A and Rap1B proteins. The beta subunit is responsible for peptide-binding.

Subunit:
Heterodimer of an alpha and a beta subunit.

Similarity:
Belongs to the protein prenyltransferase subunit beta family.
Contains 4 PFTB repeats.

Gene ID:
5229

PGGT1B,香叶烯基转移酶1β抗体Database links:
Entrez Gene: 5229 Human
Entrez Gene: 225467 Mouse
Entrez Gene: 81746 Rat
Omim: 602031 Human
SwissProt: P53609 Human
SwissProt: Q8BUY9 Mouse
SwissProt: P53610 Rat
Unigene: 254006 Human
Unigene: 262096 Mouse
Unigene: 393044 Mouse
Unigene: 10031 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.