FITC标记的早期B淋巴细胞因子2抗体
产品名称： FITC标记的早期B淋巴细胞因子2抗体
英文名称： Anti-EBF2/FITC
产品编号： HZ-11740R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-EBF2/FITC Conjugated antibody
FITC标记的早期B淋巴细胞因子2抗体
| 产品编号 | bs-11740R-FITC |
| 英文名称 | Anti-EBF2/FITC |
| 中文名称 | FITC标记的早期B淋巴细胞因子2抗体 |
| 别 名 | COE 2; COE2; Collier Olf and EBF 2; Early B cell factor 2; EBF 2; FLJ11500; Metencephalon mesencephalnon olfactory transcription factor 1; O/E 3; O/E3; OE 3; OE3; OLF 1/EBF like 3; Transcription factor COE2; COE2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 63kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EBF2 (331-400aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Early B-cell factor 2 is a 575 amino acid protein belonging to the COE family of proteins, whose members are all helix-loop-helix transcription factors. EBF2 is a transcription factor which, in synergy with the Wnt-responsive LEF1/CTNNB1 pathway, activates the decoy receptor for RANKL, OPG, in osteoblasts. OPG, in turn, regulates osteoclast differentiation. Lack of EBF2 has been found to cause a small defect in the terminal differentiation of osteoblasts, along with reduced bone mass and an increase in osteoclasts. Localized to the nucleus, EBF2 forms a homodimer or a heterodimer with a related family member. Function: EBF2 (Early B-cell factor 2) belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors. In osteoblasts it activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. EBF2 acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. It recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Subunit: Forms either a homodimer or a heterodimer with a relatedfamily member Subcellular Location: Nuclear Similarity: Belongs to the COE family. Contains 1 IPT/TIG domain. Database links: UniProtKB/Swiss-Prot: Q9HAK2.4 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
早期B细胞因子2是属于COE家族蛋白的575个氨基酸，其成员均为螺旋-环-螺旋转录因子。EBF2是一种转录因子，它与Wnt应答的LeF1/CTNNB1通路协同作用，激活成骨细胞中RANKL、OPG的诱饵受体。OPG，反过来，调节破骨细胞分化。缺乏EBF2已经发现在成骨细胞的终末分化中产生小的缺陷，伴随着骨量减少和破骨细胞的增加。EBF2定位于细胞核，与相关家族成员形成同源二聚体或异源二聚体。