FITC标记的信号传导T淋巴细胞活化相关蛋白抗体
产品名称： FITC标记的信号传导T淋巴细胞活化相关蛋白抗体
英文名称： Anti-SH2D1A/FITC
产品编号： HZ-9873R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-SH2D1A/FITC Conjugated antibody
FITC标记的信号传导T淋巴细胞活化相关蛋白抗体
| 产品编号 | bs-9873R-FITC |
| 英文名称 | Anti-SH2D1A/FITC |
| 中文名称 | FITC标记的信号传导T淋巴细胞活化相关蛋白抗体 |
| 别 名 | SH2 domain protein 1A; DSHP; Duncan disease SH2 protein; SAP; Signaling lymphocyte activation molecule associated protein; SLAM associated protein; T cell signal transduction molecule SAP; SH21A_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 免疫学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 14kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SH2D1A/SAP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 产品介绍 | background: SH2D1A, also SH2 domain protein 1A, SAP and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, influences signaling pathways involving SLAM molecules at the interface between T and B cells. SH2D1A modulates SLAM by blocking the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM. SLAM activation mediates expansion of activated T cells during immune responses, induces production of interferon-?and changes the functional profile of subsets of T cells. SH2D1A is a hydrophilic, 128 amino acid protein that is 96% homologous to the mouse protein in both SH2 and tail domains. SH2D1A is present in all major subsets of T cells, including CD4+, CD45RO+, CD45RA+ and CD8+, but not in B cells. SH2D1A can interact via an SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of cell-surface receptors SLAM (CD150), CD84, CD229 (LY9) and CD244 (2B4). Function: Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. Subunit: Interacts with NTRK1, NTRK2 and NTRK3 (By similarity). Interacts with CD84, CD244, LY9, SLAMF1 and FYN. Subcellular Location: Cytoplasmic Tissue Specificity: Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis. DISEASE: Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma. Similarity: Contains 1 SH2 domain. Database links: Entrez Gene: 4068 Human Entrez Gene: 20400 Mouse Entrez Gene: 501502 Rat Omim: 300490 Human SwissProt: O60880 Human SwissProt: O88890 Mouse SwissProt: B2RZ59 Rat Unigene: 349094 Human Unigene: 441197 Mouse Unigene: 12605 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SH2D1A，SH2结构域蛋白1A，SAP和CD150／SLAM（信号转导淋巴细胞活化分子）相关蛋白，影响SLAM分子在T细胞和B细胞之间的界面上的信号通路。SH 2D1A通过阻断酪氨酸磷酸酶Spp2向SLAM磷酸化胞质结构域的调控来调节SLAM。SLAM激活介导免疫应答过程中活化T细胞的扩增，诱导干扰素的产生？并改变T细胞亚群的功能分布。SH2D1A是一种亲水性的128氨基酸蛋白，与SH2和尾部结构域的小鼠蛋白同源96%。SH 2D1A存在于T细胞的所有主要亚群中，包括CD4+、CD45 RO+、CD45 rA+和CD8+，但不在B细胞中。SH2D1A可以通过SH2结构域与细胞表面受体SLAM（CD150）、CD84、CD229（LY9）和CD244（2B4）的胞质尾部中存在的基序（TyYXXV）相互作用。