FITC标记的信号转导和转录激活因子4抗体
产品名称： FITC标记的信号转导和转录激活因子4抗体
英文名称： Anti-STAT4/FITC
产品编号： HZ-10023R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-STAT4/FITC Conjugated antibody
FITC标记的信号转导和转录激活因子4抗体
| 英文名称 | Anti-STAT4/FITC |
| 中文名称 | FITC标记的信号转导和转录激活因子4抗体 |
| 别 名 | signal transducers and activators of transduction 4; CIS4; HSPC060; SOCS4; SOCS6; SSI4; STAI4; STAT 4; STAT4; STATI4; Suppressor of cytokine signaling 6; STAT4_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 发育生物学 信号转导 细胞凋亡 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 85kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human STAT4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]. Function: Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling. Subunit: Forms a homodimer or a heterodimer with a related family member. Interacts with ARL2BP. The SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain. Subcellular Location: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. Post-translational modifications: Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity. DISEASE: Genetic variations in STAT4 are associated with susceptibility to systemic lupus erythematosus type 11 (SLEB11) [MIM:612253]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Genetic variations in STAT4 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Similarity: Belongs to the transcription factor STAT family. Contains 1 SH2 domain. Database links: Entrez Gene: 6775 Human Entrez Gene: 20849 Mouse Entrez Gene: 367264 Rat Omim: 600558 Human SwissProt: Q14765 Human SwissProt: P42228 Mouse SwissProt: Q66HB2 Rat Unigene: 735572 Human Unigene: 80642 Human Unigene: 1550 Mouse Unigene: 137580 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由该基因编码的蛋白质是STAT家族转录因子的成员。作为对细胞因子和生长因子的响应，STAT家族成员被受体相关激酶磷酸化，然后形成同源或异源二聚体，这些同源或异源二聚体迁移到细胞核，在那里它们充当转录激活剂。该蛋白对介导淋巴细胞IL12的应答和调节辅助性T细胞的分化是必需的。该基因的突变可能与系统性红斑狼疮和类风湿性关节炎有关。交替剪接导致编码同一蛋白质的多个转录变体。[由RefSeq，Aug 2011提供]。