PTCH monoclonal antibody (M06), clone 3B7
产品名称: PTCH monoclonal antibody (M06), clone 3B7
英文名称: PTCH monoclonal antibody (M06), clone 3B7
产品编号: H00005727-M06
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant PTCH.
- Immunogen:
- PTCH (NP_000255, 841 a.a. ~ 940 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- PKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQAN
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2a Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
- MSDS:
- Download
- Applications
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged PTCH is approximately 1ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 5727
- GeneBank Accession#:
- NM_000264
- Protein Accession#:
- NP_000255
- Gene Name:
- PTCH1
- Gene Alias:
- BCNS,FLJ26746,FLJ42602,HPE7,NBCCS,PTC,PTC1,PTCH,PTCH11
- Gene Description:
- patched homolog 1 (Drosophila)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq
- Other Designations:
- OTTHUMP00000021709,OTTHUMP00000021710,PTCH protein +12b,PTCH protein +4',PTCH protein -10,patched
- Related Disease
- Basal Cell Nevus Syndrome
- Breast cancer
- Breast Neoplasms
- Carcinoma, Basal Cell
- Carcinoma, Ductal, Breast
- Carcinoma, Hepatocellular
- Carcinoma, Lobular
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Diabetes Mellitus, Type 2
- Disease Susceptibility
- Edema
- Genetic Predisposition to Disease
- Jaw Neoplasms
- Liver Neoplasms
- Lung Diseases
- Odontogenic Cysts