HMW Cytokeratin,高分子量细胞角蛋白抗体

产品编号HZ-18058R
英文名称HMW Cytokeratin
中文名称高分子量细胞角蛋白抗体
别 名CK 13; CK 14; CK 15; CK 16; CK13; CK14; CK15; CK16; Cytokeratin 13; Cytokeratin 14; Cytokeratin 15; Cytokeratin 16; EBS3; EBS4; K13; K14; K15; K16; K1CO; K1CP; Keratin 13; Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); Keratin 14; Keratin 15; Keratin 15, basic; Keratin 15, beta; Keratin 16 (focal non epidermolytic palmoplantar keratoderma); Keratin 16; Keratin, type I cytoskeletal 13; Keratin, type I cytoskeletal 16; KRT13; KRT14; KRT15; KRT16; KRT16A; KRTB; NEPPK; NFJ; Type I cytoskeletal 15.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 细胞类型标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Horse,
HMW Cytokeratin,高分子量细胞角蛋白抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量51kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human HMW Cytokeratin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
HMW Cytokeratin,高分子量细胞角蛋白抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]

Function:
Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue. There are two types of Cytokeratins: the low weight, acidic type I cytokeratins and the high weight, basic or neutral type II. Cytokeratins are usually found in pairs comprising a type I Cytokeratin and a type II cytokeratin. The high molecular weight cytokeratins, which are the basic or neutral cytokeratins, comprise subtypes CK1 (67), CK2 (65.5), CK3 (64), CK4 (59), CK5 (58), CK6 (56), CK7 (54), CK8 (52.5) and CK9. The low molecular weight cytokeratins, which are the acidic cytokeratins, comprise subtypes CK10 (56.5), CK12 (56), CK13 (53), CK14 (50), CK16( 48), CK17 (46), CK18 (45), CK19(48) and CK20(46).

Subunit:
Heterotetramer of two type I and two type II keratins.disulfide-linked keratin-14 associates with keratin-5. Interacts with TRADD and with keratin filaments. Associates with other type I keratins.

Subcellular Location:
Cytoplasmic

Similarity:
Belongs to the intermediate filament family.

Gene ID:
3860

HMW Cytokeratin,高分子量细胞角蛋白抗体Database links:
Entrez Gene: 408039 Chicken
Entrez Gene: 408040 Chicken
Entrez Gene: 507464 Cow
Entrez Gene: 3860 Human
Entrez Gene: 3861 Human
Entrez Gene: 3866 Human
Entrez Gene: 3868 Human
Entrez Gene: 16663 Mouse
Entrez Gene: 16664 Mouse
Entrez Gene: 16665 Mouse
Entrez Gene: 16666 Mouse
Entrez Gene: 287699 Rat
Entrez Gene: 287700 Rat
Entrez Gene: 287701 Rat
Entrez Gene: 303530 Rat
Omim: 148030 Human
Omim: 148065 Human
Omim: 148066 Human
Omim: 148067 Human
SwissProt: Q6PVZ1 Chicken
SwissProt: Q17QL7 Cow
SwissProt: P02533 Human
SwissProt: P08779 Human
SwissProt: P13646 Human
SwissProt: P19012 Human
SwissProt: P08730 Mouse
SwissProt: Q61414 Mouse
SwissProt: Q61781 Mouse
SwissProt: Q9Z2K1 Mouse
SwissProt: Q6IFV1 Rat
SwissProt: Q6IFV3 Rat
SwissProt: Q6IFV4 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.