EIF6抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
EIF6抗体

EIF6抗体

商家询价

产品名称： EIF6抗体

英文名称： EIF6Antibody

产品编号： XY10291-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 EIF6抗体

Applications
In-house applications ELISA, WB, IHC     Application not tested? Please see our Guarantee.
Published applications WB Publications 4 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human
Images
Prev1NextView more validation data
  • 10291-1-AP;COLO 320 cellCOLO 320 cells were subjected to SDS PAGE followed by western blot with 10291-1-AP(EIF6 antibody) at dilution of 1:1000
  • 10291-1-AP;Prostate cancerImmunohistochemical of paraffin-embedded human prostate cancer using 10291-1-AP(EIF6 antibody) at dilution of 1:50 (under 10x lens)
Positive WB detected in COLO 320 cells, A375 cells, HEK-293 cells, HeLa cells, HepG2 cells, mouse liver tissue
Positive IHC detected in Human prostate cancer tissue
Recommended dilution WB : 1:500-1:5000
IHC : 1:20-1:200
 EIF6抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen EIF6 fusion protein ag0324 Full name Eukaryotic translation initiation factor 6
Calculated molecular
weight		 27 kDa Observed molecular 
weight		 27-30 kDa
GenBank accession 
number		 BC001119 Gene ID (NCBI) 3692
Gene symbol EIF6 Synonyms 2, b, b(2)gcn, B(2)GCN homolog, CAB, eIF 6, EIF3A, EIF6, gcn, integrin beta 4 binding protein, ITGB4BP, p27(BBP), p27BBP
Background EIF6抗体

P27(BBP/eIF6) is an evolutionarily conserved protein that was originally identified as p27(BBP), It functions as an interactor of the cytoplasmic domain of integrin 4 and as the putative translation initiation factor eIF6. p27BBP is found in two pools: one nuclear pool enriched in the perinucleolar region, and one cytoplasmic pool. p27BBP binds to the fibronectin type III domains of integrin 4 subunit (ITGB4), an important functional component of hemidesmosomes, and help link ITGB4 to the intermediate filament cytoskeleton. In vitro and in vivo studies demonstrated that p27BBP is essential for cell viability and has a primary function in the biogenesis of the 60S ribosomal subunit. p27BBP protein is increased in rapidly cycling cells and decreased in villous cells committed to apoptotic cell death. In dysplastic colorectal adenomas and carcinomas, p27BBP displayed a large increase of its nucleolar component and was associated with the nuclear matrix. In particular, p27BBP increased progressively from adenomas to carcinomas and was related to the tumor stage. EIF6抗体

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