FITC标记的Erbin蛋白抗体
产品名称： FITC标记的Erbin蛋白抗体
英文名称： Anti-Erbin/FITC
产品编号： HZ-20310R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Erbin/FITC Conjugated antibody
FITC标记的Erbin蛋白抗体
| 英文名称 | Anti-Erbin/FITC |
| 中文名称 | FITC标记的Erbin蛋白抗体 |
| 别 名 | Densin-180-like protein; Erbb2-interacting protein; ERBB2IP; Erbin; LAP2; LAP2_HUMAN; Protein LAP2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 158kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Erbin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] Function: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state Subunit: Interacts with ERBB2, BPAG1 and ITGB4. May favor the localization of ERBB2, by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin. Interacts (via C-terminus) with DST Isoform 3 (via N-terminus). Tissue Specificity: Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine. Similarity: Belongs to the LAP (LRR and PDZ) protein family. Contains 17 LRR (leucine-rich) repeats. Contains 1 PDZ (DHR) domain. Database links: Entrez Gene: 55914 Human Entrez Gene: 59079 Mouse Omim: 606944 Human SwissProt: Q96RT1 Human SwissProt: Q80TH2 Mouse Unigene: 519346 Human Unigene: 591774 Human Unigene: 597241 Human Unigene: 277354 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因是富含亮氨酸重复序列和PDZ结构域（LAP）家族的成员。编码的蛋白质含有17个富含亮氨酸的重复序列和一个PDZ结构域。它与ERBB2蛋白的非磷酸化形式结合，调节ERBB2的功能和定位。它还通过干扰Ras-Raf相互作用来影响Ras信号通路。已观察到该基因的另一种剪接转录体变异体编码多种异构体。[ RefSeq，2011月11日]