FITC标记的原钙粘蛋白β2抗体
产品名称： FITC标记的原钙粘蛋白β2抗体
英文名称： Anti-PCDHB2/FITC
产品编号： HZ-11136R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PCDHB2/FITC Conjugated antibody
FITC标记的原钙粘蛋白β2抗体
| 产品编号 | bs-11136R-FITC |
| 英文名称 | Anti-PCDHB2/FITC |
| 中文名称 | FITC标记的原钙粘蛋白β2抗体 |
| 别 名 | MGC111392; PCDH beta 2; PCDH beta2; PCDHB 2; Protocadherin beta 2; PCDB2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞粘附分子 细胞骨架 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 84kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PCDHB2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes.PCDHB2 (protocadherin beta 2), whose alternative names include MGC111392 or PCDH-BETA2, is one of 16 proteins in the protocadherin beta cluster, and contains 798 amino acids. PCDHB2 is a single-pass type I membrane protein which is involved in maintaining specific neuronal connections in the brain. PCDHB2 contains six cadherin domains and has a potential role in calcium-dependent cell-adhesion.Unlike the alpha and gamma gene clusters whose genes are spliced to downstream constant region exons during transcription, members of the beta cluster (such as PCDHB2) do not use constant-region exons to produce mRNAs. As a result, each protocadherin beta gene encodes the transmembrane, extracellular and short cytoplasmic domains of the protein. Function: PCDHB2 is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. It is a potential neural cadherin-like calcium-dependent cell-adhesion protein and may be involved in the establishment and maintenance of specific neuronal connections in the brain. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Similarity: Contains 6 cadherin domains. Database links: Entrez Gene: 56133 Human Omim: 606328 Human SwissProt: Q9Y5E7 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
原粘蛋白是一大类钙黏蛋白样细胞粘附蛋白，参与脑内神经元连接的建立和维持。共有三个原粘蛋白基因簇，命名为α、β和γ，它们都含有多个排列排列的基因。PCDHB2（原粘蛋白β2），其代号为MGC111392或PCDH-BETA2，是原粘蛋白β簇中的16种蛋白质之一，包含798个阿明。O酸。PCDHB2是一种单通道I型膜蛋白，参与维持脑内的特异性神经元连接。PCDHB2含有6个钙黏蛋白结构域，在钙依赖性细胞粘附中具有潜在作用。不同于α和γ基因簇，其基因在转录过程中被剪接到下游恒定区外显子，β簇（如PCDHB2）的成员不使用恒定区域外显子T。o产生mRNA。结果，每个原粘蛋白β基因编码蛋白质的跨膜、胞外和短胞质结构域。