ARL8B,ADP核糖基化样因子8B抗体

产品编号HZ-20099R
英文名称ARL8B
中文名称ADP核糖基化样因子8B抗体
别 名ADP ribosylation factor like 10C; ADP-ribosylation factor-like protein 10C; ADP-ribosylation factor-like protein 8B; ARL10C; ARL8B; ARL8B_HUMAN; FLJ10702; Gie1; Novel small G protein indispensable for equal chromosome segregation 1.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞周期蛋白 细胞分化 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Cow, Rabbit,
ARL8B,ADP核糖基化样因子8B抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ARL8B
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ARL8B,ADP核糖基化样因子8B抗体PubMedPubMed
产品介绍background:
ADP-ribosylation factors (ARFs) are highly conserved guanine nucleotide binding proteins that enhance the ADP-ribosyltransferase activity of Cholera Toxin. ARF’s are important in eukaryotic vesicular trafficking pathways and they play an essential role in the activation of phospholipase D (PC-PLD). ARL8B (ADP-ribosylation factor-like protein 8B), also known as ARL10C or GIE1, is a 186 amino acid protein that localizes to the late endosome membrane and belongs to the ARL family of ARF-like GTPase proteins. Expressed ubiquitously, ARL8A interacts with Tubulin and is thought to play a role in lysosome motility, as well as in chromosomal segregation. The gene encoding ARL8B maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.

Function:
May play a role in lysosome motility (PubMed:16537643). May play a role in chromosome segregation (PubMed:15331635).

Subunit:
Interacts with tubulin.

Subcellular Location:
Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle.

Tissue Specificity:
Ubiquitously expressed.

ARL8B,ADP核糖基化样因子8B抗体Similarity:
Belongs to the small GTPase superfamily. Arf family.

Gene ID:
55207

Database links:
Entrez Gene: 55207 Human
SwissProt: Q9NVJ2 Human
Unigene: 250009 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.