POP1,感染性蛋白唯一蛋白1抗体

产品编号HZ-9107R
英文名称POP1
中文名称感染性蛋白唯一蛋白1抗体
别 名PAAD domain only protein; POP1; PYDC1; Pyrin domain containing 1; Pyrin only protein 1; PYDC1_HUMAN.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Horse,
POP1,感染性蛋白唯一蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量10kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ASC2/POP1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
POP1,感染性蛋白唯一蛋白1抗体PubMedPubMed
产品介绍background:
The death domain (DD) superfamily of proteins share one or more of the following domains: the DD, DED (death-effector domain), CARD (caspase-recruitment domain) and PYD (Pyrin domain). Each of these domains is characterized by a canonical death domain fold, which consists of a bundle of five or six antiparallel α-helices. As their names suggest, these domains play prominent roles in programmed cell death. ASC2 (apoptosis-associated speck-like protein containing a CARD 2), also known as Pyrin-only protein 1 or PADD-only protein 1, is an 89 amino acid member of the DD superfamily that contains one Pyrin domain. Localized to the cytoplasm, ASC2 interacts with ASC to modulate NF-κB and pro-caspase-1 regulation. ASC2 is predominantly expressed in monocytes, macrophages and granulocytes.

Function:
Associates with apoptosis-associated specklike proteincontaining a CARD domain (ASC) and modulates its ability tocollaborate with pyrin and cryopyrin in NF-kappa-B andpro-caspase-1 activation. Suppresses kinase activity of NF-kappa-Binhibitor kinase (IKK) complex, expression of NF-kappa-B induciblegenes and inhibits NF-kappa-B activation by cytokines and LPS.

POP1,感染性蛋白唯一蛋白1抗体Subunit:
Interacts with PYCARD/ASC.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Predominantly expressed in monocytes,macrophages and granulocytes.

Post-translational modifications:
Phosphorylated.

Similarity:
Contains 1 DAPIN domain.

Database links:
UniProtKB/Swiss-Prot: Q8WXC3.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.