CDKN2D/p19 INK4d,细胞周期蛋白依赖性激酶抑制剂2D抗体

产品编号HZ-5982R
英文名称CDKN2D/p19 INK4d
中文名称细胞周期蛋白依赖性激酶抑制剂2D抗体
别 名CDK inhibitor p19INK4d; CDKN2D; cell cycle inhibitor, Nur77 associating protein; Cyclin dependent kinase inhibitor 2D; Cyclin-dependent kinase 4 inhibitor D; Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); inhibitor of cyclin-dependent kinase 4d; INK4D; p19; p19-INK4D; p19INK4d; Similar to cyclin-dependent kinase inhibitor 2D; CDN2D_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 染色质和核信号 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
CDKN2D/p19 INK4d,细胞周期蛋白依赖性激酶抑制剂2D抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量18kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CDKN2D/p19 INK4d
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CDKN2D/p19 INK4d,细胞周期蛋白依赖性激酶抑制剂2D抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008].

Function:
Interacts strongly with CDK4 and CDK6 and inhibits them.

Subunit:
Interacts with CDK6.

Subcellular Location:
Nucleus. Cytoplasm.

Similarity:
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Contains 4 ANK repeats.

Database links:
Entrez Gene: 510244 Cow
Entrez Gene: 1032 Human
Entrez Gene: 12581 Mouse
Entrez Gene: 494444 Rat
Omim: 600927 Human
SwissProt: Q29RV0 Cow
SwissProt: P55273 Human
SwissProt: Q60773 Mouse
Unigene: 435051 Human
Unigene: 29020 Mouse

CDKN2D/p19 INK4d,细胞周期蛋白依赖性激酶抑制剂2D抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.