Product: Anti-EDG-2 (CT) pAb
Cat. No.: PC-086 (100 μg)
Synonyms:
Lysophospholipid receptor A1, Vzg-1, mrec1.3
or GPCR26.
Background:
Endothelial cell differentiation gene-2 (EDG-2)
receptor is a high affinity receptor for
lysophosphatidic acid (LPA). EDG-2, like all
other EDG receptors, couple multiple (3 or more)
types of G proteins and transduction decreases
in c[AMP]i through Gi and increases in [Ca+2]i by
augmenting phospholipase C through Gq/11 and
beta/gamma dimers and by induction of PI3
kinase, p125 FAK, phospholipase D by
activating rho through G12/13. Human EDG-2 is
present in high levels on oligodendrocytes and
certain human malignant T cell lines. EDG-2
receptors (with EDG-4) may play a role in
protecting cardiomyocytes from apoptosis
induced by hypoxia and andrenergic stimulation.
Specificity:
Reacts with EDG-2.
Species Reactivity:
Human and Rat. Other species not tested.
Ig Isotype:
Rabbit IgG
Immunogen:
KLH conjugated synthetic peptide
corresponding to the AA 328-344 of human
EDG-2.
Epitope:
Recognizes an epitope on human EDG-2
between AA 328-344.
Format:
Rabbit polyclonal antibody against human
endothelial cell differentiation gene 2 (CT). This
antibody is provided as a 0.2 μm sterile-filtered
solution in PBS with 0.08% sodium azide at a
concentration of 1 mg/mL. Assayed to be >95%
purity by SDS PAGE.
Storage:
Store at -20°C. Aliquot to avoid freeze/thaw
cycles.
Application and Suggested Dilutions:

Western blotting: Use at approximately 1
μg/mL. This antibody detects a band of about
50 kDa.
The optimal dilution for a specific application
should be determined by the researcher.
Limitations:
For in vitro research use only. Not for use in
diagnostics or in humans.
Warranty:
No warranties, expressed or implied, are made
regarding the use of this product. KAMIYA
BIOMEDICAL COMPANY is not liable for any
damage, personal injury, or economic loss
caused by this product.