FITC标记的磷酸化鸟苷酸转换因子VAV1抗体
产品名称： FITC标记的磷酸化鸟苷酸转换因子VAV1抗体
英文名称： Anti-phospho-VAV1 (Tyr160)/FITC
产品编号： HZ-5593R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-phospho-VAV1 (Tyr160)/FITC Conjugated antibody
FITC标记的磷酸化鸟苷酸转换因子VAV1抗体
| 英文名称 | Anti-phospho-VAV1 (Tyr160)/FITC |
| 中文名称 | FITC标记的磷酸化鸟苷酸转换因子VAV1抗体 |
| 别 名 | VAV1(phospho Y160); Oncogene vav; p95Vav; Protooncogene vav; Proto-oncogene vav; VAV 1; VAV 1 oncogene; VAV; Vav proto oncogene; Vav proto-oncogene; VAV_HUMAN; VAV1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 免疫学 染色质和核信号 信号转导 转录调节因子 激酶和磷酸酶 G蛋白偶联受体 t-淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 98kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human VAV1 around the phosphorylation site of Tyr160 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]. Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. Subunit: May interact with CCPG1. Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB and CLNK. Interacts with THEMIS2. Interacts with HCK. Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with PTK2B/PYK2. Interacts (via SH2 domain) with SYK. Interacts with ANKRD54. Tissue Specificity: Widely expressed in hematopoietic cells but not in other cell types. Post-translational modifications: Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS). Phosphorylated by FYN. Similarity: Contains 1 CH (calponin-homology) domain. Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 SH2 domain. Contains 2 SH3 domains. Database links: Entrez Gene: 7409 Human Entrez Gene: 22324 Mouse Entrez Gene: 25156 Rat Omim: 164875 Human SwissProt: P15498 Human SwissProt: P27870 Mouse SwissProt: P54100 Rat Unigene: 116237 Human Unigene: 248172 Mouse Unigene: 48861 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Vav1蛋白是特异于造血细胞表达的鸟苷酸转换因子,它参与了多种免疫细胞如T细胞,B细胞,巨噬细胞,自然杀伤性细胞等的胞内信号转导,发挥着重要作用. Vav1主要参与T细胞信号传导途径，传导信号激活钙流、细胞外信号调节激酶（ERK）以及转录因子NFκB。Vav1蛋白在T细胞生长发育、成熟T细胞激活、细胞因子合成及细胞骨架活动中发挥重要作用 |
This is of the VAV基因家族成员的基因。茶是变风量蛋白核苷酸交换因子（GEF）酸的Rho家族GTP酶和肌动蛋白细胞骨架的途径，对该alterations rearrangements和转录。is the important编码蛋白在造血的作用，打在T细胞和B细胞的发展和激活。has been the编码蛋白特异性结合的合作伙伴identified as the of Nef蛋白的HIV - 1从。共表达与形态学结合的合作伙伴initiates of these changes rearrangements潜心，SAPK / JNK的细胞骨架和信号转导级联，该病毒转录和increased levels of to REPLICATION。alternatively spliced have been variants成绩单编码到多isoforms for this基因。[提供]序列模式，2012年4月。