CD28 monoclonal antibody, clone CD28.2 (PerCP)
产品名称： CD28 monoclonal antibody, clone CD28.2 (PerCP)
英文名称： CD28 monoclonal antibody, clone CD28.2 (PerCP)
产品编号： MAB5124
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against CD28.
- Immunogen:
- Native from DC28.1.3.3 hybridoma cells.
- Host:
- Mouse
- Reactivity:
- Human, Primates
- Specificity:
- This antibody reacts with CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of MW 44 KDa) which is a critical costimulatory receptor of T cells.
- Form:
- Liquid
- Conjugation:
- PerCP
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (0.2% BSA, 15 mM sodium azide)
- Storage Instruction:
- Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (10 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primates.
Jeong SH, Qiao M, Nascimbeni M, Hu Z, Rehermann B, Murthy K, Liang TJ.J Virol. 2004 Jul;78(13):6995-7003.
- 2.
- Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling.
Scharschmidt E, Wegener E, Heissmeyer V, Rao A, Krappmann D.Mol Cell Biol. 2004 May;24(9):3860-73.
- 3.
- Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6.
Marti F, Krause A, Post NH, Lyddane C, Dupont B, Sadelain M, King PD.J Immunol. 2001 Jan 1;166(1):197-206.
- 4.
- Evidence that Langerhans cells in adult pulmonary Langerhans cell histiocytosis are mature dendritic cells: importance of the cytokine microenvironment.
Tazi A, Moreau J, Bergeron A, Dominique S, Hance AJ, Soler P.J Immunol. 1999 Sep 15;163(6):3511-5.
- 5.
- Expression of a variant of CD28 on a subpopulation of human NK cells: implications for B7-mediated stimulation of NK cells.
Galea-Lauri J, Darling D, Gan SU, Krivochtchapov L, Kuiper M, Gaken J, Souberbielle B, Farzaneh F.J Immunol. 1999 Jul 1;163(1):62-70.
- Application Image
- Flow Cytometry
- Entrez GeneID:
- 940
- Gene Name:
- CD28
- Gene Alias:
- MGC138290,Tp44
- Gene Description:
- CD28 molecule
- Omim ID:
- 186760
- Gene Ontology:
- Hyperlink
- Gene Summary:
- CD28 costimulation is essential for CD4 (MIM 186940)-positive T-cell proliferation, survival, interleukin-2 (IL2; MIM 147680) production, and T-helper type-2 (Th2) development.[supplied by OMIM
- Other Designations:
- CD28 antigen,CD28 antigen (Tp44),T-cell-specific surface glycoprotein
- Related Disease
- Acute Disease
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Behcet Syndrome
- Bronchiolitis, Viral
- Carcinoma, Squamous Cell
- Celiac Disease
- Cholangitis, Sclerosing
- Colon cancer
- Colorectal Neoplasms
- Diabetes Mellitus, Type 1
- Disease Progression
- Drug Eruptions
- Genetic Predisposition to Disease
- Hematologic Diseases
- Hepatitis C
- Hodgkin Disease
- Hypersensitivity, Immediate