CSFV Envelope glycoprotein E2,猪瘟病毒包膜糖蛋白E2抗体

产品编号HZ-4527R
英文名称CSFV Envelope glycoprotein E2
中文名称猪瘟病毒包膜糖蛋白E2抗体
别 名polyprotein [Classical swine fever virus]; polyprotein; CSFV polyprotein; E2; Envelope glycoprotein E2; structural protein E2 [Classical swine fever virus]; POLG_CSFVA.
说 明 书0.1ml 0.2ml
研究领域细菌及病毒
抗体来源Rabbit
克隆类型Polyclonal
交叉反应CSFV
CSFV Envelope glycoprotein E2,猪瘟病毒包膜糖蛋白E2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from CSFV Envelope glycoprotein E2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CSFV Envelope glycoprotein E2,猪瘟病毒包膜糖蛋白E2抗体PubMedPubMed
产品介绍background:
Classical swine fever(CSF) is a kind of acute and intense contagious disease in swine, it material damages swine industry. CSF could cause swine appearing disseminated hemorrhage in systemic organ and tissue, degeneration and necrosis in small vascular and capillary endothelial cells. Classical swine fever virus (CSFV) belongs to genera Pestivirus, family Flaviviridae, it’s genome total length is 12.3Kb,including a big ORF, encoding 11 structural and nonstructural proteins.
Envelope glycoprotein E2 exists in the form of homodimer; this protein is cleaved from the polyprotein by a cellular signal peptidase.

CSFV Envelope glycoprotein E2,猪瘟病毒包膜糖蛋白E2抗体Function:
E(rns), E1 and E2 are responsible of cell attachment and subsequent fusion of viral and cellular membrane. P7 forms a leader sequence to properly orient NS2 in the membrane. Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus. NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity. RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.

Subunit:
The E(rns) glycoprotein is found as a homodimer; disulfide-linked. The E1 and E2 envelope glycoproteins form disulfide-linked homodimers as well as heterodimers.

Subcellular Location:
E(rns) glycoprotein: Host membrane; Peripheral membrane protein. Note: The C-terminus membrane anchor of Erns represents an amphipathic helix embedded in plane into the membrane

DISEASE:

Similarity:
Belongs to the pestivirus polyprotein family.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain. Contains 1 peptidase C53 domain.
Contains 1 peptidase C74 domain.
Contains 1 peptidase S31 domain.
Contains 1 RdRp catalytic domain.

Gene ID:
920146

CSFV Envelope glycoprotein E2,猪瘟病毒包膜糖蛋白E2抗体Database links:
Entrez Gene: 920146 CSFVA
SwissProt: P19712 CSFVA

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.