分子量:30.7 kDa

纯度:>90% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human CD38, His Tag by the LAL method.

Buffer:50 mM MES, pH 6.5 with 100 mM NaCl

生物活性:

产品特性:Human CD38, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 30.7 kDa. The predicted N-terminus is Val 43. The reducing (R) protein migrates as 30-45 kDa in SDS-PAGE  due to glycosylation.

产品背景:CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.