MECP2 monoclonal antibody (M04A), clone 2E8
产品名称: MECP2 monoclonal antibody (M04A), clone 2E8
英文名称: MECP2 monoclonal antibody (M04A), clone 2E8
产品编号: H00004204-M04A
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant MECP2.
- Immunogen:
- MECP2 (AAH11612, 81 a.a. ~ 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- PKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQ
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2a Kappa
- Storage Buffer:
- In ascites fluid
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (35.53 KDa) .
- MSDS:
- Download
- Application Image
- Western Blot (Recombinant protein)
- ELISA
- Entrez GeneID:
- 4204
- GeneBank Accession#:
- BC011612
- Protein Accession#:
- AAH11612
- Gene Name:
- MECP2
- Gene Alias:
- AUTSX3,DKFZp686A24160,MRX16,MRX79,MRXS13,MRXSL,PPMX,RTS,RTT
- Gene Description:
- methyl CpG binding protein 2 (Rett syndrome)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq
- Other Designations:
- OTTHUMP00000026021,methyl CpG binding protein 2
- Related Disease
- Alzheimer disease
- Angelman Syndrome
- Angelman syndrome
- Attention Deficit Disorder with Hyperactivity
- Autistic Disorder
- Brain Diseases
- Cardiovascular Diseases
- Child Development Disorders, Pervasive
- Chromosome Aberrations
- Cognition Disorders
- Developmental Disabilities
- Diabetes Mellitus, Type 2
- Disease Progression
- Edema
- Epilepsy
- Epilepsy
- Fractures, Bone
- Fragile X Syndrome
- Fragile X syndrome