FARP2,鸟嘌呤核苷酸交换因子FARP2抗体

产品编号HZ-11459R
英文名称FARP2
中文名称鸟嘌呤核苷酸交换因子FARP2抗体
别 名FARP 2; FERM; FGD1 related Cdc42 GEF; FIR; FRG; KIAA0793; PLEKHC3; RhoGEF and pleckstrin domain protein 2; FARP2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Horse,
FARP2,鸟嘌呤核苷酸交换因子FARP2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量120kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FARP2 (601-700aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FARP2,鸟嘌呤核苷酸交换因子FARP2抗体PubMedPubMed
产品介绍background:
FARP2 is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons. FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from plexin-A1, thereby activating FARP2's Rac GEF activity which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism.

Function:
FARP2 is a Rho-guanine nucleotide exchange factor that activates RAC1. It plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton.

Subunit:
Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding

Similarity:
Contains 1 DH (DBL-homology) domain.
Contains 1 FERM domain.
Contains 2 PH domains.

Gene ID:
9855

FARP2,鸟嘌呤核苷酸交换因子FARP2抗体Database links:
Entrez Gene: 9855 Human
Entrez Gene: 227377 Mouse
SwissProt: O94887 Human
SwissProt: Q91VS8 Mouse
Unigene: 726316 Human
Unigene: 243091 Mouse
Unigene: 28761 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.