DNAJA1,热休克蛋白相关蛋白4抗体

产品编号HZ-11277R
英文名称DNAJA1
中文名称热休克蛋白相关蛋白4抗体
别 名DJ 2; DJ2; DjA1; DnaJ (Hsp40) homolog, subfamily A, member 1; DnaJ homolog subfamily A member 1; DnaJ protein homolog 2; DNAJ2; Dnaja1; DNJA1_HUMAN; hDJ 2; HDJ-2; HDJ2; Heat shock 40 kDa protein 4; HSP 40-4; heat shock protein DNAJ like 2; Heat shock protein J2; HSDJ; HSJ-2; HSJ2; HSPF4; Human DnaJ protein 2; NEDD7; Neural precursor cell expressed developmentally down regulated 7; OTTHUMP00000021193.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
DNAJA1,热休克蛋白相关蛋白4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量45kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human HSP 40-4 (21-110aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DNAJA1,热休克蛋白相关蛋白4抗体PubMedPubMed
产品介绍background:
DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.

Function:
Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria.

Subcellular Location:
Membrane.

Similarity:
Contains 1 CR-type zinc finger.
Contains 1 J domain.

Database links:
Entrez Gene: 3301 Human
Entrez Gene: 15502 Mouse
Entrez Gene: 100512008 Pig
Entrez Gene: 65028 Rat
Omim: 602837 Human
SwissProt: P31689 Human
SwissProt: P63037 Mouse
SwissProt: P63036 Rat
Unigene: 445203 Human
Unigene: 27897 Mouse
Unigene: 64562 Rat

DNAJA1,热休克蛋白相关蛋白4抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.