ABCG2 polyclonal antibody
产品名称： ABCG2 polyclonal antibody
英文名称： ABCG2 polyclonal antibody
产品编号： PAB3158
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ABCG2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human ABCG2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Flow cytometry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells.
Xie Y, Xu K, Linn DE, Yang X, Guo Z, Shimelis H, Nakanishi T, Ross DD, Chen H, Fazli L, Gleave ME, Qiu Y.J Biol Chem. 2008 Feb 8;283(6):3349-56. Epub 2007 Dec 5.
- 2.
- In vitro evaluation of photosensitivity risk related to genetic polymorphisms of human ABC transporter ABCG2 and inhibition by drugs.
Tamura A, Onishi Y, An R, Koshiba S, Wakabayashi K, Hoshijima K, Priebe W, Yoshida T, Kometani S, Matsubara T, Mikuriya K, Ishikawa T.Drug Metab Pharmacokinet. 2007 Dec;22(6):428-40.
- Entrez GeneID:
- 9429
- Protein Accession#:
- NP_004818;Q9UNQ0
- Gene Name:
- ABCG2
- Gene Alias:
- ABC15,ABCP,BCRP,BCRP1,BMDP,CD338,CDw338,EST157481,MGC102821,MRX,MXR,MXR1
- Gene Description:
- ATP-binding cassette, sub-family G (WHITE), member 2
- Omim ID:
- 603756
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. [provided by RefSeq
- Other Designations:
- ABC transporter,ATP-binding cassette transporter G2,ATP-binding cassette, sub-family G, member 2,breast cancer resistance protein,mitoxantrone resistance protein,placenta specific MDR protein
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Atherosclerosis
- Atherosclerosis
- Brain Ischemia
- Brain Neoplasms
- Breast cancer
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Renal Cell
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Colon cancer
- Colorectal Neoplasms
- Coronary Artery Disease
- Coronary Disease
- Crohn's disease
- Diabetes Complications
- Diabetes Mellitus, Type 2