CD177,嗜中性粒细胞抗原CD177抗体

产品编号HZ-10962R
英文名称CD177
中文名称嗜中性粒细胞抗原CD177抗体
别 名NB1 GP; PRV-1; PRV1; HNA-2a; NB1 glycoprotein; Neutrophil Glycoprotein NB1; RGD1562941; CD177 antigen; Polycythemia rubra vera protein 1; Human neutrophil alloantigen 2a; HNA-2a; CD177; NB1; CD177_HUMAN.
说 明 书0.1ml 0.2ml
研究领域免疫学 细胞表面分子 糖蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Dog, Cow, Horse, Guinea Pig,
CD177,嗜中性粒细胞抗原CD177抗体产品应用IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量48kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CD177
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD177,嗜中性粒细胞抗原CD177抗体PubMedPubMed
产品介绍background:
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
Highly expressed in normal bone marrow and weakly expressed in fetal liver. Expressed on neutrophils. Expressed in granulocytes of patients with polycythemia vera (PV) and with essential thrombocythemia (ET).

Similarity:
Contains 2 UPAR/Ly6 domains.

Gene ID:
57126

Database links:
Entrez Gene: 57126 Human
Omim: 162860 Human
SwissProt: Q8N6Q3 Human
Unigene: 232165 Human

CD177,嗜中性粒细胞抗原CD177抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.