AADACL1,中性胆固醇酯水解酶1抗体

产品编号HZ-5162R
英文名称AADACL1
中文名称中性胆固醇酯水解酶1抗体
别 名Arylacetamide deacetylase like 1; Arylacetamide deacetylase-like 1; Kiaa1363; NCEH; Nceh1; NCEH1_HUMAN; Neutral cholesterol ester hydrolase 1; Neutral cholesterol ester hydrolase.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 信号转导 肿瘤细胞生物标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
AADACL1,中性胆固醇酯水解酶1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量46kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human AADACL1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
AADACL1,中性胆固醇酯水解酶1抗体PubMedPubMed
产品介绍background:
The assembly of very-low-density lipoproteins (VLDLs) in the secretory apparatus of the hepatocyte relies on the mobilization of triacylglycerol (TAG) from the cytosolic pool by lipolysis and re-esterification. However, some of the re-esterified TAG products are returned to the cytosolic pool in the liver, which protects vulnerable body tissues from excess lipotoxic non-esterified fatty acids in the plasma. Some of the lipases involved in this process include arylacetamide deacetylase (AADAC) and its related proteins AADACL1 and AADACL2. AADAC, a single pass type II membrane protein of the endoplasmic reticulum, is expressed in hepatocytes, intestinal mucosal cells, pancreas and adrenal gland. It plays an important role in the metabolic activation of arylamine substrates to ultimate carcinogens. AADACL1 hydrolyzes the metabolic intermediate 2-acetyl monoalkylglycerol, and its inactivation results in disruption of ether lipid metabolism in cancer cells and impaired cell migration and tumor growth.

Function:
Hydrolyzes 2-acetyl monoalkylglycerol ether, thepenultimate precursor of the pathway for de novo synthesis ofplatelet-activating factor. May be responsible for cholesterolester hydrolysis in macrophages, thereby contributing to thedevelopment of atherosclerosis. Also involved in organdetoxification by hydrolyzing exogenous organophosphorus compounds.May contribute to cancer pathogenesis by promoting tumor cellmigration.

Subcellular Location:
Membrane; Single-pass type II membraneprotein (Probable). Microsome

AADACL1,中性胆固醇酯水解酶1抗体Tissue Specificity:
Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the 'GDXG' lipolytic enzyme family.

Gene ID:
57552

Database links:
Entrez Gene: 57552 Human
Entrez Gene: 320024 Mouse
Omim: 613234 Human
SwissProt: Q6PIU2 Human
SwissProt: Q8BLF1 Mouse
Unigene: 444099 Human
Unigene: 24576 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.