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上海信裕生物科技有限公司
Caspase 1/p20/p10抗体

Caspase 1/p20/p10抗体

商家询价

产品名称： Caspase 1/p20/p10抗体

英文名称： Caspase 1/p20/p10Antibody

产品编号： XY22915-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 CASPASE 1/P20/P10抗体

Applications
In-house applications ELISA, WB, IF     Application not tested? Please see our Guarantee.
Species specificity Human, Mouse, Rat; other species not tested.
Images
Prev1NextView more validation data
  • 22915-1-AP;Jurkat cellsJurkat cells were subjected to SDS PAGE followed by western blot with 22915-1-AP(CASP1 antibody) at dilution of 1:1000
  • 22915-1-AP;C6 cellsImmunofluorescent analysis of C6 cells using 22915-1-AP( Caspase 1 Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Positive WB detected in Jurkat cells, C6 cells, HeLa cells, MCF7 cells, MDA-MB-453s cells, NIH/3T3 cells, Raji cells, RAW264.7 cells
Positive IF detected in C6 cells
Recommended dilution WB : 1:500-1:5000
IF : 1:10-1:100
 CASPASE 1/P20/P10抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen Affinity purified
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information CASPASE 1/P20/P10抗体
Immunogen Caspase 1/p20/p10 fusion protein ag11143 Full name Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Calculated molecular
weight		 404aa,45 kDa Observed molecular 
weight		 45-47 kDa,30 kDa,35 kDa
GenBank accession 
number		 BC062327 Gene ID (NCBI) 834
Gene symbol CASP1 Synonyms CASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, Interleukin 1 beta convertase, p10, p20, P45
Background

CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing. 22915-1-AP can recognize all the five isoforms of caspase 1. It also can recognize p45 procaspase and the mature fragments p10 and p20. CASPASE 1/P20/P10抗体

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