FITC标记的尿激酶型纤溶酶原激活因子受体抗体
产品名称： FITC标记的尿激酶型纤溶酶原激活因子受体抗体
英文名称： Anti-uPA Receptor/FITC
产品编号： HZ-1927R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-uPA Receptor/FITC Conjugated antibody
FITC标记的尿激酶型纤溶酶原激活因子受体抗体
| 英文名称 | Anti-uPA Receptor/FITC |
| 中文名称 | FITC标记的尿激酶型纤溶酶原激活因子受体抗体 |
| 别 名 | PLAUR; Plasminogen activator,urokinase receptor; Urokinase plasminogen activator surface receptor; Monocyte activation antigen Mo3; uPAR; U-PAR; MO3; UPAR; CD 87; CD87; CD87 antigen; MO 3; MO3; Monocyte activation antigen Mo3; Plasminogen activator urokinase receptor; U PAR; u plasminogen activator receptor; UPA receptor; UPAR; Urinary plasminogen activator receptor; URKR; Urokinase plasminogen activator receptor; Urokinase plasminogen activator surface receptor. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 免疫学 信号转导 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PLAUR |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol(GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq]. Function: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Subcellular Location: Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor. Isoform 2: Secreted (Probable). Tissue Specificity: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. Similarity: Contains 3 UPAR/Ly6 domains. Database links: Entrez Gene: 5329 Human Entrez Gene: 18793 Mouse Entrez Gene: 50692 Rat Omim: 173391 Human SwissProt: Q03405 Human SwissProt: P35456 Mouse SwissProt: P49616 Rat Unigene: 466871 Human Unigene: 1359 Mouse Unigene: 82711 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码尿激酶型纤溶酶原激活剂受体，并赋予其在定位和促进纤溶酶形成中的作用，可能影响与细胞表面纤溶酶原激活和细胞外基质的局部降解有关的许多正常和病理过程。它既结合尿激酶纤溶酶原激活剂的前体蛋白和成熟形式，又允许纤溶酶激活受体结合的前体酶。蛋白质缺乏跨膜或胞质结构域，并可由糖基磷脂酰肌醇（GPI）部分锚定到质膜上，在其羧基末端附近的新生多肽裂解。然而，在某些细胞类型中也产生可溶性蛋白。选择性剪接导致多个转录子变体编码不同的亚型。前蛋白经历了几个尚未完全定义的翻译后裂解反应。[由RefSeq提供]。