FITC标记的锌指/环指蛋白2抗体
产品名称： FITC标记的锌指/环指蛋白2抗体
英文名称： Anti-ZNRF2/FITC
产品编号： HZ-9140R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-ZNRF2/FITC Conjugated antibody
FITC标记的锌指/环指蛋白2抗体
| 产品编号 | bs-9140R-FITC |
| 英文名称 | Anti-ZNRF2/FITC |
| 中文名称 | FITC标记的锌指/环指蛋白2抗体 |
| 别 名 | E3 ubiquitin-protein ligase ZNRF2; Protein Ells2; RING finger protein 202; Zinc/RING finger protein 2; Znrf2; ZNRF2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZNRF2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, as well as the endosome and the cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM. Function: May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Subunit: Interacts with UBE2N. Subcellular Location: Endosome membrane. Lysosome membrane. Cell junction > synapse > presynaptic cell membrane. Present in presynaptic plasma membranes in neurons. Tissue Specificity: Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 RING-type zinc finger. Database links: Entrez Gene: 223082 Human Entrez Gene: 387524 Mouse Entrez Gene: 362367 Rat Omim: 612061 Human SwissProt: Q8NHG8 Human SwissProt: Q71FD5 Mouse Unigene: 487869 Human Unigene: 286149 Mouse Unigene: 392146 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
泛素化是一个重要的机制，通过它，三类酶协同作用于短命或异常蛋白质以破坏。泛素化涉及的三类酶是泛素激活酶（E1S）、泛素结合酶（E2S）和泛素蛋白连接酶（E3S）。ZnrF2（锌和环指2）也称为RNF202，是一种242氨基酸的外周膜蛋白，含有一个环型锌指，并定位于溶酶体，以及内涵体和细胞连接处。在脑组织中高表达，ZnFR2被认为是一种E3泛素蛋白连接酶，可能参与神经元的传递和可塑性的建立和维持。DNA损伤时，ZnrF2可能受到磷酸化，可能是ATR或ATM。