FITC标记的细胞表面趋化因子受体5抗体
产品名称： FITC标记的细胞表面趋化因子受体5抗体
英文名称： Anti-CCR5/FITC
产品编号： HZ-2514R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-CCR5/FITC Conjugated antibody
FITC标记的细胞表面趋化因子受体5抗体
| 英文名称 | Anti-CCR5/FITC |
| 中文名称 | FITC标记的细胞表面趋化因子受体5抗体 |
| 别 名 | C-C chemokine receptor 5; CCR5; CC-CKR-5;CCR-5; CCCKR5; CD195; CD 195; CKR-5; CKR5; CMKBR5; FLJ78003; IDDM22; AM4-7; C C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A; CC Chemokine Receptor Type 5; CCR5 chemokine (C C motif) receptor 5; Chemokine receptor CCR5; CHEMR13; HIV 1 Fusion Coreceptor; HIV1 fusion coreceptor; IDDM22; MIP-1 alpha receptor; CCR5_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞膜受体 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CCR-5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]. Function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. Subunit: Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Interacts with human cytomegalovirus/HHV-5 protein UL78. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1A and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 1234 Human Entrez Gene: 12774 Mouse Entrez Gene: 117029 Rat Omim: 601373 Human SwissProt: P51681 Human SwissProt: P51682 Mouse SwissProt: O08556 Rat Unigene: 450802 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
该基因编码β趋化因子受体家族的成员，其预测为与G蛋白偶联受体相似的七跨膜蛋白。这种蛋白是由T细胞和巨噬细胞表达的，并被认为是巨噬细胞嗜酸病毒（包括HIV）进入宿主细胞的重要共受体。该基因的缺陷等位基因与HIV感染抗性相关。该受体的配体包括单核细胞趋化蛋白2（MCP-2）、巨噬细胞炎性蛋白1α（MIP-1α）、巨噬细胞炎性蛋白1β（MIP-1β），并对活化的正常T表达和分泌蛋白（RANTES）进行调节。该基因在原髓母细胞系中也有表达，提示该蛋白可能参与粒细胞系增殖和分化。该基因位于趋化因子受体基因簇区。已经发现了两个编码相同蛋白的转录变体。[由RefSeq提供]。