CLEC2,C型凝集素结构域家族1成员B抗体

产品编号HZ-2543R
英文名称CLEC2
中文名称C型凝集素结构域家族1成员B抗体
别 名 C-type lectin domain family 1 member B; 1810061I13Rik; C type lectin domain family 1 member B; C type lectin like receptor 2; C-type lectin domain family 1, member B; C-type lectin-like receptor-2; CLEC 2; CLEC 2B; CLEC-2; CLEC2; CLEC2B; PRO1384; QDED721; CLC1B_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Cow,
CLEC2,C型凝集素结构域家族1成员B抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量27kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CLEC2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CLEC2,C型凝集素结构域家族1成员B抗体PubMedPubMed
产品介绍background:
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]

Function:
Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.

Subunit:
Homodimer.

Subcellular Location:
Membrane; Single-pass type II membrane protein (Probable).

Tissue Specificity:
Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.

Post-translational modifications:
Glycosylated.
Phosphorylated on tyrosine residue in response to rhodocytin binding.

CLEC2,C型凝集素结构域家族1成员B抗体Similarity:
Contains 1 C-type lectin domain.

Gene ID:
51266

Database links:
Entrez Gene: 51266 Human
Omim: 606783 Human
SwissProt: Q9P126 Human
Unigene: 221418 Human
Unigene: 409794 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.