Iterative Crystallography Service：Neurotrophic Factor Artemin Isoform 3
产品名称： Iterative Crystallography Service：Neurotrophic Factor Artemin Isoform 3
英文名称： Iterative Crystallography Service：Neurotrophic Factor Artemin Isoform 3
产品编号：
产品价格： 询价
产品产地： null
品牌商标： null
更新时间： null
使用范围： null
- 联系人 :
- 地址 : 北京市通州区经海五路1号院22号楼
- 邮编 :
- 所在区域 : 北京
- 电话 : 158****7462 点击查看
- 传真 : 点击查看
- 邮箱 : info@abace-biology.com
http://www.creative-biostructure.com/Iterative-crystallography/Iterative-crystallography-CBCRY32.htm
|
Cat. No. |
CBCRY32 |
|
|
Background |
Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET. |
|
|
Molecular description |
Protein Classification |
Hormone/growth Factor |
|
Structure Weight |
11574.40 Da |
|
|
Polymer |
1 |
|
|
Molecule |
neurotrophic factor artemin isoform 3 |
|
|
Chain Length |
105 amino acids |
|
|
Crystal Description |
PDB ID |
|
|
MMDB ID |
||
|
Source |
E.coli |
|
|
Method |
X-Ray Diffraction |
|
|
Resolution |
1.76Å |
|
|
Gene information |
Gene Name |
|
|
Synonyms |
ENOVIN; EVN; NBN; OTTHUMP00000009173; OTTHUMP00000009174; neublastin; neurotrophic factor; neurotrophic factor artemin |
|
|
UniProt ID |
||
|
GeneID |
||
|
Chromosome Location |
1p33-p32 |
|
|
Function |
growth factor activity; receptor binding |
|
|
Reference |
Wang, X., Baloh, R.H., Milbrandt, J., Garcia, K.C. (2006) Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure 14: 1083-1092 |
|