FITC标记的巢蛋白NID2抗体
产品名称： FITC标记的巢蛋白NID2抗体
英文名称： Anti-Nidogen 2/FITC
产品编号： HZ-9717R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Nidogen 2/FITC Conjugated antibody
FITC标记的巢蛋白NID2抗体
| 产品编号 | bs-9717R-FITC |
| 英文名称 | Anti-Nidogen 2/FITC |
| 中文名称 | FITC标记的巢蛋白NID2抗体 |
| 别 名 | NID 2; NID2; Nidogen2; Osteonidogen; NID2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 信号转导 干细胞 细胞周期蛋白 细胞分化 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 19kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from hu Nanos3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Nidogens are highly conserved proteins present in vertebrate and invertebrate basement membranes. Nidogens connect the Laminin and Collagen IV networks and integrate other proteins into the membrane. In mammals, two Nidogen proteins, Nidogen and Nidogen-2, interact at comparable levels with Collagen I, IV and Perlecan, serving to stabilize basement membranes and playing a major role in embryogenesis. The two isoforms have a similar shape, consisting of three globular domains, and co-localize in vessel walls and other basement membrane zones. Nidogen-2 is a cell adhesion protein glycosylated at nitrogen and oxygen sites, and is widely distributed in basement membranes in heart, placenta, bone and, to a lesser extent, in pancreas, kidney and skeletal muscle. Function: Nidogen 2 is an adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell extracellular matrix interactions. Subcellular Location: Secreted Database links: Entrez Gene: 22795 Human Entrez Gene: 18074 Mouse Omim: 605399 Human SwissProt: Q14112 Human SwissProt: O88322 Mouse Unigene: 147697 Human Unigene: 369840 Human Unigene: 20348 Mouse
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
巢蛋白是脊椎动物和无脊椎动物基底膜中高度保守的蛋白质。Nidogens连接层粘连蛋白和胶原IV网络，并将其他蛋白质整合到膜中。在哺乳动物中，两种胰岛素原蛋白，NIDGEN和NIDGION-2，在与胶原I、IV和Perlecan相当的水平上相互作用，用于稳定基底膜并在胚胎发生中发挥主要作用。这两种亚型具有相似的形状，由三个球状结构域组成，共定位于血管壁和其他基底膜区。NIDGION-2是一种在氮、氧部位糖基化的细胞黏附蛋白，广泛分布于心脏、胎盘、骨骼等基底膜中，在胰腺、肾脏和骨骼肌中的分布较轻。