TRPM8,“冷”蛋白TRPM8抗体

产品编号HZ-9045R
英文名称TRPM8
中文名称“冷”蛋白TRPM8抗体
别 名LTrpC-6; LTrpC6 antibody Short form of the TRPM8 cationic channel; Transient receptor potential cation channel subfamily M member 8; Transient receptor potential p8; Trp p8; Trp-p8; Trpm8; TRPM8_HUMAN; TRPP8; MGC2849; transient receptor potential-p8; Long transient receptor potential channel 6.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 神经生物学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Sheep,
TRPM8,“冷”蛋白TRPM8抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量128kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human TRPM8
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
TRPM8,“冷”蛋白TRPM8抗体PubMedPubMed
产品介绍background:
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

Function:
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

Subunit:
Homotetramer (By similarity).

Subcellular Location:
Membrane; Multi-pass membrane protein (Probable).

TRPM8,“冷”蛋白TRPM8抗体Tissue Specificity:
Expressed in prostate. Also expressed in most in prostate tumors. Also expressed in non-prostatic primary tumors such as colon, lung, breast and skin tumors.

Similarity:
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 ub-subfamily.

Database links:
Entrez Gene: 79054 Human
Entrez Gene: 171382 Mouse
Entrez Gene: 171384 Rat
Omim: 606678 Human
SwissProt: Q7Z2W7 Human
SwissProt: Q8R4D5 Mouse
SwissProt: Q8R455 Rat
Unigene: 366053 Human
Unigene: 218753 Mouse
Unigene: 81225 Rat

TRPM8,“冷”蛋白TRPM8抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

TRPM8与感应热和辣的蛋白质属于同一家族，它存在于特定神经细胞的细胞膜上，成为响应外界信号的开关通道。科学家研究发现，当温度低于27摄氏度或者醇存在的条件下，TRPM8通道都会打开，使钙离子等带正电的粒子进入细胞。 TRPM8的蛋白质在产生冷知觉的过程中起着主导作用，并且控制着低温对机体疼痛的缓解效果, TRPM8故称是“冷”蛋白。