ERAL1/GTP binding protein era homolog,ERAL1蛋白抗体

产品编号HZ-16364R
英文名称ERAL1/GTP binding protein era homolog
中文名称ERAL1蛋白抗体
别 名CEGA; Conserved ERA like GTPase; Conserved ERA-like GTPase; ERA; Era (E. coli G protein homolog) like 1; Era G protein like 1 (E. coli); Era G protein like 1; ERA W; ERA-like protein 1; ERA-W; Eral1; ERAL1_HUMAN; ERAL1A; ERAW; GTP binding protein era homolog; GTPase Era; GTPase Era, mitochondrial; GTPase human homolog of E. coli essential cell cycle protein Era; H-ERA; HERA A; hERA; HERA B; HERAA; HERAB; mitochondrial.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Sheep,
ERAL1/GTP binding protein era homolog,ERAL1蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量43kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ERAL1/GTP binding protein era homolog
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ERAL1/GTP binding protein era homolog,ERAL1蛋白抗体PubMedPubMed
产品介绍background:
CEGA is a 437 amino acid human homolog of Era. Functioning as a probable GTP-binding protein, ERAL1 contains the same structural domains as its yeast counterpart, namely a conserved BoxA sequence, a C-terminal KH domain and an N-terminal GTP-binding domain. Due to the high level of structural similarity with Era, ERAL1 may participate in cell cycle events, including cellular proliferation and cell division. ERAL1 contains one KH type-2 domain and is expressed as two isoforms, designated HERA-A and HERA-B, which are produced due to alternative splicing events.

Function:
Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

Subcellular Location:
Mitochondrion matrix. Mitochondrion inner membrane. Localizes on the matrix side on the mitochondrial inner membrane.

DISEASE:

ERAL1/GTP binding protein era homolog,ERAL1蛋白抗体Similarity:
Belongs to the Era/MnmE GTP-binding protein family. Era subfamily.
Contains 1 G (guanine nucleotide-binding) domain.
Contains 1 KH type-2 domain.

Gene ID:
26284

Database links:
Entrez Gene: 26284 Human
Entrez Gene: 57837 Mouse
Entrez Gene: 363646 Rat
Omim: 607435 Human
SwissProt: O75616 Human
SwissProt: Q9CZU4 Mouse
SwissProt: Q5EBA0 Rat
Unigene: 3426 Human
Unigene: 21096 Mouse
Unigene: 99076 Rat

ERAL1/GTP binding protein era homolog,ERAL1蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.