Prostaglandin I2 Receptor,前列环素受体抗体

产品编号HZ-11307R
英文名称Prostaglandin I2 Receptor
中文名称前列环素受体抗体
别 名IP; PGI receptor; PGI2 receptor; PI2R_HUMAN; PRIPR; Prostacyclin receptor; Prostaglandin I2 receptor; Prostanoid IP receptor; PTGIR.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 信号转导 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
Prostaglandin I2 Receptor,前列环素受体抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量41kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Prostaglandin I2 Receptor
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Prostaglandin I2 Receptor,前列环素受体抗体PubMedPubMed
产品介绍background:
Cyclooxygenases metabolize arachidonate to five primary prostanoids: PGE2, PGF2?, PGI2, TXA2 and PGD2. These lipid mediators interact with specific members of G protein-coupled prostanoid receptors, designated EP, FP, IP, TP and DP, respectively. The IP Receptor binds prostacyclin, PGI2, the main pro-stanoid synthesized by vascular tissues.Upon binding to the IP Receptor, prostacyclin activates adenylate cyclase primarily through the Gas protein. The gene encoding the human IP Receptor is located on chromosome 19. It is expressed as a glycosylated and phosphorylated protein, which is abundantly expressed in vascular tissues such as aorta, lung, atrium and ventricle, as well as in kidney, thymus, spleen and neurons.

Function:
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

Subcellular Location:
Cell membrane.

Post-translational modifications:
Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling. Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.

Prostaglandin I2 Receptor,前列环素受体抗体Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:
UniProtKB/Swiss-Prot: P43119.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.