Neurogenin 1,神经元素1抗体

产品编号HZ-8570R
英文名称Neurogenin 1
中文名称神经元素1抗体
别 名AKA; Ath4c; bHLHa6; Class A basic helix-loop-helix protein 6; Helix loop helix protein mATH 4C; MATH4C; NeuroD3; Neurog 1; Neurog1; Neurogenic basic helix loop helix protein; Neurogenic basic-helix-loop-helix protein; Neurogenic differentiation 3; Neurogenic differentiation factor 3; Neurogenin-1; Neurogenin1; Ngn; NGN-1; Ngn1; NGN1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 干细胞 细胞类型标志物 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow,
Neurogenin 1,神经元素1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量26kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human NGN1/Neurogenin 1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Neurogenin 1,神经元素1抗体PubMedPubMed
产品介绍background:
The neurogenin family of proteins belongs to the basic helix-loop-helix (bHLH) superfamily and consists of neurogenin 1, neurogenin 2 and neurogenin 3 (also designated ngn3). bHLH members are transcriptional regulators that determine cell fate. During mouse neurogenesis, Neurogenin 1 and Neurogenin 2 are expressed in distinct progenitor populations in the central and peripheral nervous systems. Targeted mutation analyses have shown that Neurogenin 1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia and that Neurogenin 2 is essential for the determination of precursors for epibranchial placode-derived sensory neurons. The gene which encodes Neurogenin 1 maps to human chromosome 5q23-q31.

Subunit:
Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expression restricted to the embryonic nervous system.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

Database links:

UniProtKB/Swiss-Prot: Q92886.2

Neurogenin 1,神经元素1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.