FITC标记的环指蛋白135抗体
产品名称： FITC标记的环指蛋白135抗体
英文名称： Anti-RNF135/FITC
产品编号： HZ-11753R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RNF135/FITC Conjugated antibody
FITC标记的环指蛋白135抗体
| 产品编号 | bs-11753R-FITC |
| 英文名称 | Anti-RNF135/FITC |
| 中文名称 | FITC标记的环指蛋白135抗体 |
| 别 名 | L13; MGC13061; ring finger protein 135; RN135_HUMAN . |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 转录调节因子 表观遗传学 环指蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RNF135 (288-360aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF135 (RING finger protein 135), also known as L13, is a 432 amino acid protein that contains one RING-type zinc finger and one SPRY domain. Via its RING-type zinc finger, RNF135 may play a role in transcriptional regulation and protein degradation events. Defects in the gene encoding RNF135 are the cause of RNF135-related overgrowth syndrome which is characterized by learning disabilities, facial dysmorphism and increased weight and height. Multiple isoforms of RNF135 exist due to alternative splicing events. Function: The protein encoded by RNF135 contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Subunit: Interacts with DDX58. Interacts with PCBP2. Subcellular Location: Cytoplasmic Tissue Specificity: Expressed in skeletal muscle, spleen, kidney,placenta, prostate, stomach, thyroid and tongue. Also weaklyexpressed in heart, thymus, liver and lung. Post-translational modifications: Defects in RNF135 are the cause of macrocephalymacrosomia facial dysmorphism syndrome (MMFD) [MIM:614192]. MMFD isan autosomal dominant disorder characterized by the association ofmacrothrombocytopathy and progressive sensorineural hearing losswithout renal dysfunction. Similarity: Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger. Database links: UniProtKB/Swiss-Prot: Q8IUD6.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
环型锌指基序存在于许多病毒和真核蛋白质中，并且由能够结合两个锌原子的保守的富含半胱氨酸的结构域构成。含有保守结构域的蛋白质一般参与蛋白质降解的泛素化途径。RNF135（环指蛋白135），又称L13，是含有一个环状锌指和一个SRY结构域的432氨基酸蛋白。RNF135可通过其环状锌指蛋白在转录调控和蛋白降解事件中发挥作用。RNF135基因的缺陷是RNF135相关的过度生长综合征的原因，其特征是学习障碍、面部畸形和体重和身高的增加。RNF135的多个异构体由于选择性剪接事件而存在。