CIRBP,冷诱导RNA结合蛋白抗体

产品编号HZ-7790R
英文名称CIRBP
中文名称冷诱导RNA结合蛋白抗体
别 名A18 hnRNP; A18HNRNP; cirbp; CIRBP_HUMAN; CIRP; Cold inducible RNA binding protein; Cold-inducible RNA-binding protein; Glycine rich RNA binding protein; Glycine-rich RNA-binding protein CIRP.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 细胞周期蛋白 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow,
CIRBP,冷诱导RNA结合蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量19kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CIRBP
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CIRBP,冷诱导RNA结合蛋白抗体PubMedPubMed
产品介绍background:
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.

Function:
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.

Subunit:
Interacts with EIF4G1. Associates with ribosomes.

Subcellular Location:
Nucleus, nucleoplasm. Cytoplasm.

Tissue Specificity:
Ubiquitous.

CIRBP,冷诱导RNA结合蛋白抗体Post-translational modifications:
Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity).
Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation.

Similarity:
Contains 1 RRM (RNA recognition motif) domain.

Database links:

UniProtKB/Swiss-Prot: Q14011.1
Entrez Gene: 1153 Human
Entrez Gene: 425789 Chicken
Entrez Gene: 507120 Cow
Entrez Gene: 476755 Dog
Entrez Gene: 12696 Mouse
Entrez Gene: 81825 Rat
Omim: 602649 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.