Other Recombinant Proteins
Recombinant Human Lin28-TAT





 





		Synonyms :
CSDD1, LIN28A, ZCCHC1



		Description :
Lin28 is a RNA-binding protein that belongs to a diverse family of structurally-related transcription factors.  Lin28 is found abundantly in embryonic stem cells (ESCs), and to a lesser extent in placenta and testis.   Lin28 has been shown to block let-7 microRNA processing and maturation, a necessary step in the differentiation of stem cells and certain cancer cell lines.  Together with Sox2, Oct4, and Nanog, Lin28 can induce the reprogramming of primary human fibroblasts to a pluripotent state.  Lin28 and other regulatory proteins can be introduced into cells by DNA transfection, viral infection, or microinjection.  Protein transduction using TAT fusion proteins represents an alternative methodology for introducing proteins into primary as well as transformed cells.  Recombinant human Lin28-TAT is a 24.4 kDa protein containing 222 amino acid residues, including 13- residue C-terminal TAT peptide.



		Catalog #:
110-06



		Source :
E.coli



		Purity :
Greater than 90% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Measured by its ability to induce fluorescence in Lin28 reporter cells (293 cells transfected with fluorescent protein genes under Lin28 control). Optimum activity was achieved at 20 μg/ml after incubation for 72 hr.



                AA Sequence :
GPSVSNQQFA GGCAKAAEEA PEEAPEDAAR AADEPQLLHG AGICKWFNVR MGFGFLSMTA RAGVALDPPV DVFVHQSKLH MEGFRSLKEG EAVEFTFKKS AKGLESIRVT GPGGVFCIGS ERRPKGKSMQ KRRSKGDRCY NCGGLDHHAK ECKLPPQPKK CHFCQSISHM VASCPLKAQQ GP 



		PubMed Link :
Lin28


Country of Origin :
USA
















        Size A
5μg
$80 
 


 



        Size B
25μg
$195 
 


 



        Size C
1mg
$3000 
 


 















Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.