Proteasome 20S beta 3,蛋白酶体PSMβ3抗体

产品编号HZ-9357R
英文名称Proteasome 20S beta 3
中文名称蛋白酶体PSMβ3抗体
别 名20S Proteasome β3; C10 II; HC10 II; proteasome (prosome, macropain) subunit, beta type 3; Proteasome beta 3 subunit; Proteasome chain 13; proteasome component C10 II; Proteasome theta chain; PSMB3.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞周期蛋白 细胞分化
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,
Proteasome 20S beta 3,蛋白酶体PSMβ3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Proteasome 20S beta 3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Proteasome 20S beta 3,蛋白酶体PSMβ3抗体PubMedPubMed
产品介绍background:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring shaped 20S core structure. The core structure is composed of 4 rings of 28 non identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin dependent process in a non lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.

Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Subunit:
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with HIV-1 TAT protein.

Subcellular Location:
Cytoplasmic and Nuclear

Proteasome 20S beta 3,蛋白酶体PSMβ3抗体Similarity:
Belongs to the peptidase T1B family.

Gene ID:
5691

Database links:
Entrez Gene: 5691 Human
Entrez Gene: 26446 Mouse
Entrez Gene: 29676 Rat
Omim: 602176 Human
SwissProt: P33672 Cow
SwissProt: P49720 Human
SwissProt: Q9R1P1 Mouse
SwissProt: P40112 Rat
Unigene: 82793 Human
Unigene: 94551 Rat

Proteasome 20S beta 3,蛋白酶体PSMβ3抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.