FITC标记的泛素激活酶2/泛素激活酶E1相关蛋白抗体
产品名称： FITC标记的泛素激活酶2/泛素激活酶E1相关蛋白抗体
英文名称： Anti-UBE1L / UBE2/FITC
产品编号： HZ-3814R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-UBE1L / UBE2/FITC Conjugated antibody
FITC标记的泛素激活酶2/泛素激活酶E1相关蛋白抗体
| 英文名称 | Anti-UBE1L / UBE2/FITC |
| 中文名称 | FITC标记的泛素激活酶2/泛素激活酶E1相关蛋白抗体 |
| 别 名 | UBA1B; UBE1L; D8; UBA7; Ube 1L; UBE 2; Ubiquitin activating enzyme 2; Ubiquitin activating enzyme E1 homolog; Ubiquitin Activating Enzyme E1 Like; Ubiquitin activating enzyme E1 related protein; UBA7_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 112kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Ube1L |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]. Function: Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Subunit: Monomer. Binds and is involved in the conjugation of G1P2/ISG15. Tissue Specificity: Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines. Similarity: Belongs to the ubiquitin-activating E1 family. Database links: Entrez Gene: 7318 Human Entrez Gene: 74153 Mouse Entrez Gene: 301000 Rat Omim: 191325 Human SwissProt: P41226 Human Unigene: 16695 Human Unigene: 277125 Mouse Unigene: 98275 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
泛素蛋白的修饰是靶向异常或短命蛋白降解的重要细胞机制。泛素化涉及至少三类酶：泛素激活酶，或E1S，泛素结合酶，或E2S，泛素蛋白连接酶，或E3S。该基因编码E1泛素激活酶家族的成员。编码的酶是一种维甲酸靶物，其在急性早幼粒细胞白血病中触发早幼粒细胞白血病（PML）/视黄酸受体α（RARalpha）降解和凋亡，其中参与泛素样干扰素刺激的基因15蛋白的结合。[ RefSeq，JUL 2008 ]提供。