FITC标记的一氧化氮合成酶-1（神经型）抗体
产品名称： FITC标记的一氧化氮合成酶-1（神经型）抗体
英文名称： Anti-nNOS/FITC
产品编号： HZ-0156R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-nNOS/FITC Conjugated antibody
FITC标记的一氧化氮合成酶-1（神经型）抗体
| 英文名称 | Anti-nNOS/FITC |
| 中文名称 | FITC标记的一氧化氮合成酶-1（神经型）抗体 |
| 别 名 | 2310005C01Rik; bNOS; Constitutive NOS; EC 1.14.13.39; IHPS 1; IHPS1; N NOS; N-NOS; NC NOS; NC-NOS; neuronal Nitric Oxide Synthase; Neuronal NOS; Nitric oxide synthase , neuronal, included; Nitric oxide synthase 1 (neuronal); Nitric oxide synthase 1; Nitric oxide synthase brain; Nitric oxide synthase, brain; Nitric oxide synthase, penile neuronal, included; nNOS; NO; NOS 1; NOS; NOS type I; NOS-I; NOS1; NOS1_HUMAN; Peptidyl-cysteine S-nitrosylase NOS1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 130kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NOS-1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]. Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Subunit: Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity). Interacts with HTR4. Interacts with VAC14 (By similarity). Interacts with SLC6A4. Subcellular Location: Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity). Tissue Specificity: Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland. Post-translational modifications: Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro). Similarity: Belongs to the NOS family. Contains 1 FAD-binding FR-type domain. Contains 1 flavodoxin-like domain. Contains 1 PDZ (DHR) domain. Database links: Entrez Gene: 4842 Human Entrez Gene: 18125 Mouse Entrez Gene: 24598 Rat Omim: 163731 Human SwissProt: P29475 Human SwissProt: Q9Z0J4 Mouse SwissProt: P29476 Rat Unigene: 654410 Human Unigene: 684465 Human Unigene: 684466 Human Unigene: 684467 Human Unigene: 442195 Mouse Unigene: 44249 Mouse Unigene: 10573 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成与降解（Synthesis and Degradation） 一氧化氮合成酶-1催化生物体内一氧化氮（NO）生成的酶。分神经型一氧化氮合成的酶（nNOS or NOS1）、诱导型一氧化氮合成的酶（iNOS or NOS2）、内皮型一氧化氮合成的酶（eNOS or NOS3）。此抗体识别分子量为150kDa的神经型一氧化氮合成的酶 |
该基因编码的蛋白属于一氧化氮合酶家族，由L-精氨酸合成一氧化氮。一氧化氮是一种反应性自由基，在神经传递、抗菌和抗肿瘤等多种过程中起着生物媒介的作用。在大脑和外周神经系统中，一氧化氮显示出神经递质的许多特性，并与中风和神经退行性疾病相关的神经毒性、平滑肌的神经调节（包括蠕动）和**勃起有关。该蛋白在骨骼肌中普遍表达，具有较高的表达水平。已经描述了该基因的多种转录体变体，它们在5’UTR中不同，但是这些转录体的全长性质还不清楚。此外，还发现了编码不同亚型（一些睾丸特异性）的剪接转录变异体。